People
Stephen Meisenhelter, PhD
Titles:
PhD Graduate
Research:
My main interests are in how memory is encoded and recalled in humans, and how this mechanism is disrupted in epilepsy. My research mainly consists of spatial tasks in humans implanted with a chronic intracranial recorder and stimulator. Analysis of data from these experiments allows us to better understand the processes underlying memory formation and recall.
Recent Publications:
Quon RJ, Meisenhelter S, Camp EJ, Testorf ME, Song Y, Song Q, Culler GW, Moein P, Jobst BC. AiED: Artificial intelligence for the detection of intracranial interictal epileptiform discharges. Clin Neurophysiol. 2022;133:1-8. doi:10.1016/j.clinph.2021.09.018
Camp EJ, Quon RJ, Sajatovic M, Briggs F, Brownrigg B, Janevic MR, Meisenhelter S, Steimel SA, Testorf ME, Kiriakopoulos E, Mazanec MT, Fraser RT, Johnson EK, Jobst BC. Supervised machine learning to predict reduced depression severity in people with epilepsy through epilepsy self-management intervention. Epilepsy Behav. 2022;127:108548. doi:10.1016/j.yebeh.2021.108548
Quon RJ, Meisenhelter S, Adamovich-Zeitlin RH, Song Y, Steimel SA, Camp EJ, Testorf ME, MacKenzie TA, Gross RE, Lega BC, Sperling MR, Kahana MJ, Jobst BC. Factors correlated with intracranial interictal epileptiform discharges in refractory epilepsy. Epilepsia. 2021;62(2):481-491. doi:10.1111/epi.16792
Quon RJ, Leslie GA, Camp EJ, Meisenhelter S, Steimel SA, Song Y, Ettinger AB, Bujarski KA, Casey MA, Jobst BC. 40-Hz auditory stimulation for intracranial interictal activity: A pilot study. Acta Neurol Scand. 2021;144(2):192-201. doi:10.1111/ane.13437
Quon RJ, Casey MA, Camp EJ, Meisenhelter S, Steimel SA, Song Y, Testorf ME, Leslie GA, Bujarski KA, Ettinger AB, Jobst BC. Musical components important for the Mozart K448 effect in epilepsy. Sci Rep. 2021;11(1):16490. doi:10.1038/s41598-021-95922-7
Quon RJ, Camp EJ, Meisenhelter S, Song Y, Steimel SA, Testorf ME, Andrew AS, Gross RE, Lega BC, Sperling MR, Kahana MJ, Jobst BC. Features of intracranial interictal epileptiform discharges associated with memory encoding. Epilepsia. 2021;62(11):2615-2626. doi:10.1111/epi.17060
Meisenhelter S, Quon RJ, Steimel SA, Testorf ME, Camp EJ, Moein P, Culler GW, Gross RE, Lega BC, Sperling MR, Kahana MJ, Jobst BC. Interictal Epileptiform Discharges are Task Dependent and are Associated with Lasting Electrocorticographic Changes. Cereb Cortex Commun. 2021;2(2):tgab019. doi:10.1093/texcom/tgab019
Sharafeldin A, Mock VL, Meisenhelter S, Hembrook-Short JR, Briggs F. Changes in Local Network Activity Approximated by Reverse Spike-Triggered Local Field Potentials Predict the Focus of Attention. Cereb Cortex Commun. 2020;1(1):tgaa014. doi:10.1093/texcom/tgaa014
Quon RJ, Meisenhelter S, Adamovich-Zeitlin RH, Song Y, Steimel SA, Camp EJ, Testorf ME, MacKenzie TA, Gross RE, Lega BC, Sperling MR, Kahana MJ, Jobst BC. Factors correlated with intracranial interictal epileptiform discharges in refractory epilepsy. Epilepsia. Published online December 17, 2020. doi:10.1111/epi.16792
Meisenhelter S, Testorf ME, Gorenstein MA, Hasulak NR, Tcheng TK, Aronson JP, Jobst BC. Cognitive tasks and human ambulatory electrocorticography using the RNS System. J Neurosci Methods. 2019;311:408-417. doi:10.1016/j.jneumeth.2018.09.026
Miller, J., Watrous, A. J., Tsitsiklis, M., Lee, S. A., Sheth, S. A., Schevon, C. A., Smith, E. H., Sperling, M. R., Sharan, A., Asadi-Pooya, A. A., Worrell, G. A., Meisenhelter, S., Inman, C. S., Davis, K. A., Lega, B., Wanda, P. A., Das, S. R., Stein, J. M., Gorniak, R., and Jacobs, J. (2018). Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation. Nat Commun, 9(1):2423. DOI: 10.1038/s41467-018-04847-9
Meisenhelter, S., and Jobst, B. C. (2018). Neurostimulation for Memory Enhancement in Epilepsy. Current Neurology and Neuroscience Reports, 18(6). DOI: 10.1007/s11910-018-0837-3
Horak, P. C., Meisenhelter, S., Song, Y., Testorf, M. E., Kahana, M. J., Viles, W. D., Bujarski, K. A., Connolly, A. C., Robbins, A. A., Sperling, M. R., Sharan, A. D., Worrell, G. A., Miller, L. R., Gross, R. E., Davis, K. A., Roberts, D. W., Lega, B., Sheth, S. A., Zaghloul, K. A., Stein, J. M., Das, S. R., Rizzuto, D. S., and Jobst, B. C. (2017). Interictal epileptiform discharges impair word recall in multiple brain areas. Epilepsia, 58(3):373-380. DOI: 10.1111/epi.13633
Horak, P. C. , Meisenhelter, S. , Testorf, M. E. , Connolly, A. C. , Davis, K. A. and Jobst, B. C. (2015). Implementation and evaluation of an interictal spike detector. In (Eds.) SPIE Optical Engineering+ Applications.